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1, 1. recurrent and unexpected panic attacks 2, 2A. persistent concern about having additional attacks 3, 2B. worry about the implications of the attack or its consequences (e.g., losing control, having a heart attack, "going crazy") 4, 2C. a significant change in behavior related to the attacks 5, A. Both (1) and (2) 6, B.1. Presence of Agoraphobia - Anxiety about being in places or situations from which escape might be difficult (or embarrassing) or in which help might not be available in the event of having an unexpected or situationally predisposed Panic Attack or panic-like symptoms.Agoraphobic fears typically involve characteristic clusters of situations that include being outside the home alone; being in a crowd or standing in a line; being on a bridge; and traveling in a bus, train, or automobile 7, B.2. Presence of Agoraphobia - The situations are avoided (e.g., travel is restricted), or else endured with marked distress or with anxiety about having a Panic Attack or panic-like symptoms, or require the presence of a companion 8, B.3. The anxiety or phobic avoidance is not better accounted for by another mental disorder, such as Social Phobia (e.g., occurring on exposure to feared social situations); Specific Phobia (e.g., on exposure to specific phobic situations); Obsessive Compulsive Disorder (e.g., on exposure to dirt in someone with an obsession about contamination); Posttraumatic Stress Disorder (e.g., in response to stimuli associated with a severe stressor); or Separation Anxiety Disorder (e.g., in response to being away from home or close relatives). 9, C. The Panic Attacks are not due to the direct physiological effects of a substance (e.g. a drug of abuse, a medication) or general medical condition (e.g. hyperthyroidism). 10, D. The Panic Attacks are not better accounted for by another mental disorder, such as Social Phobia (e.g., occurring on exposure to feared social situations); Specific Phobia (e.g., on exposure to specific phobic situations); Obsessive Compulsive Disorder (e.g., on exposure to dirt in someone with an obsession about contamination); Posttraumatic Stress Disorder (e.g., in response to stimuli associated with a severe stressor); or Separation Anxiety Disorder (e.g., in response to being away from home or close relatives).